This is AGI: Sequoia AI Ascent 2026 Keynote

Sequoia AI Ascent 2026 — Pat Grady, Sonia & Constantine

URL: YouTube
Speakers: Pat Grady (Sequoia), Sonia (Sequoia), Constantine (Sequoia)
Date: May 2026

Tags: AI Agents AGI Venture Capital Cognitive Revolution Industrial Revolution

10 Key Takeaways

  1. AGI 已至:长周期自主 Agent(能恢复失败、持续工作)= AGI 的商业定义
  2. Services > Software:$10 万亿服务市场,Hiring agents 比雇人便宜/易扩展
  3. MAD 框架:Motes(客户关系)+ Affordance(最低阻力路径)+ Diffusion Gap(你的机会)
  4. No lead is safe:基础模型能力雷暴大雨中,没有人是安全的,任何人都能赢
  5. Services 是新软件:每个垂直行业都值得用 Agent 重做一遍
  6. 异步 Agent > 同步 Agent:Agent 衍生子 Agent 将成为主流范式
  7. 认知革命像工业革命:99% 认知工作将很快由机器完成
  8. PhD 技能将变得像铝一样:曾经珍贵,未来廉价且可随意处理
  9. Alien Design:AI 输出的结果将不符合人类直觉,需要开放心态
  10. Human Connection 是唯一持久价值:工作方式剧变,人际关系是唯一留存的东西

Part 1: Pat Grady — Overall Calibration

技术演进脉络

硅基晶体管 → 网络 → 互联网 → 云计算 → 社交媒体 → 移动设备 → AI。所有浪潮是叠加的,需要数十年积累才有今天的算力、带宽、数据、人才。

AI 浪潮的三个特点

#特点说明
1最大浪潮不仅是软件,还有服务($10 万亿级别市场)。仅美国法律服务就是 $4000 亿,等于整个软件行业
2最快浪潮空白区域正在快速被填充
3计算革命(非通信革命)互联网/云计算/移动是信息分发革命;AI 是信息处理的革命——基础每天都在变

三个重大转折点

时间事件意义
2022年11月ChatGPT 时刻世界看到了预训练的力量
两年后o1 / 模型推理第二条 Scaling Law:推理时计算
最近Claude Code +45/47长周期 Agent 的力量
"如果这不算 AGI,什么才算?当一个 Agent 可以自主完成工作、从失败中恢复并持续直到任务完成,这就是 AGI。"

从"更快的马"到"汽车"

"Cars have arrived."

MAD 框架:如何建立在模型之上

字母含义核心观点
MMotes(护城河)客户背书——客户变化远慢于技术能力变化,越围绕客户构建越持久
AAffordance(可供性)最低认知负担——为特定客户在特定问题上创建最低阻力路径
DDiffusion Gap(扩散鸿沟)模型能力创造速度 >> 企业采用速度 → 你的机会每天都在变大
"No lead is safe. Anyone can win. 赛场上有雷暴大雨时,15 辆车可以同时被超。"

Part 2: Sonia — Agents in 2026

2022 年的失败 vs. 2026 年的突破

时期案例结果
2022AutoGPT / BabyAGI失败——模型能力不足
2026Claude Code(技术人群)杀手级产品
2026OpenClaw(所有人)用手机就能用 Agent

Agent 的三个功能组件

  1. 推理与规划:基线直觉 + 实时思考
  2. 执行动作:工具调用(搜索、编写、编译)
  3. 目标迭代:持久性——跨越长时域完成任务

Agenticness 的滑动标尺

阶段范式描述
2023Tab 自动补全1个人类 + AI,1行
现在Agentic 开发1人对1 Agent,管理 Agent 团队
即将Async 异步 AgentAgent 衍生子 Agent,量级超越当前范式
前沿Dark Factories完全移除人类审查(cybersecurity 公司已在生产环境运行)
"Hiring agents is so much easier than hiring employees. 人类难扩展;Agent 用算力无限扩展。人类付工资;Agent 付 token(通常比工资便宜)"

Services = 新 Software

"Whatever you could imagine building over the next 100 years, we think is now possible in 100 days thanks to agents."

Part 3: Constantine — 认知革命的下一步

工业革命类比

物理工作(已完成)认知工作(正在发生)
1700年前:人/动物肌肉
→ 水力/风力/蒸汽/内燃/电动
今天:99%+ 物理工作由机器完成
今天:人类思考 + 少量机械辅助
→ 电子计算(数万亿计算服务人类)
神经网络:99.9% 认知工作将由机器完成
"认知革命会像工业革命一样,只是更大、更快。"

四个故事

故事 1铝的故事
25:29 1850年代:铝是最贵金属,放在 Tiffany 橱窗展示。发明电解法后数十年:铝用来包糖果、扔垃圾。
铝 = Intelligence;电解法 = AI
"PhD 级别的技能将变得像铝一样——用完即弃。"
故事 2外星设计(Alien Design)
26:28 2006年 NASA 用进化算法设计天线,结果是与人类直觉完全不同的形状,但性能远超传统设计。
当 AI 接管认知工作,结果将不符合人类直觉。 AI 设计的芯片/汽车/建筑将看起来完全不同。
故事 3新兴科学(Emerging Sciences)
27:50 工业革命前 100 年:工程师们 tinkering(敲敲打打)。120 年后:热力学诞生。
像热力学一样基础的新科学将在未来几十年出现,这个房间里的人可能发明它。
故事 4艺术的非理性(The Art of Unreason)
29:24 达盖尔银版法(1839年)出现时:"艺术已死"。人类回应:印象派、表现主义、立体主义、抽象表现主义。
"Human is the measure of all things." — Protagoras
铝没有价值;艺术没有价值;智力没有价值——它们的价值来自人类的体验和连接
"AI 可以工作,AI 将工作。但只有人类连接才能给你理由去在乎。"

Discussion Questions

  1. 你的业务中,哪些"更快的马"可以换成"汽车"?
  2. 你在构建 Motes(客户护城河)还是在追逐技术变化?
  3. 如果 PhD 技能变得像铝一样,你的技能组合如何差异化?
  4. 你如何在 Agent 大规模替代中寻找自己的位置?

Full Transcript

Pat 0:02 Good morning. How's everybody doing? 0:04 All right. All right, a little bit better. Hey, thank you all for being here. We really appreciate it. We do this as a service to the community because we are living through important times. And it's an honor for us to be able to serve as a bit of a gathering place for people to come together. And this is by far the best agenda we put together and by far the best set of attendees.
Pat 1:10 For calibration we're going to start by zooming out. Going back to the silicon based transistors which gave this area its name. They got built into systems connected by networks that went public in the form of the internet, supported applications like social media and the cloud, eventually showed up on our pockets in mobile devices that today are capable of doing something indistinguishable from magic which is AI. The reason we like to show this slide is because it reminds us that all of these waves are additive. And we sort of needed all of these decades of evolution to have the compute, the bandwidth, the data, the talent to make the most of this moment.
Pat 1:56 Now this AI wave is a little bit different in three ways. First it's the biggest wave yet. But there is something more specifically true about this wave. Which is it is the first one that is both software and services. The top row shows the first 15 years of the cloud transition where the TAM for software went from about 350 billion to 650 billion and cloud grew to be about 400 billion of that. The bottom row is what is brand new. This is the services revenue that seems to also be available now. $10 trillion is a conveniently round number. We don't know if it's 10 trillion or 5 trillion or 50 trillion. We do know that legal services in the US alone is a $400 market. That is one vertical and one geo. And it's the same as all of software. So this opportunity is immense.
Pat 2:53 Point number two: fastest wave yet. I think we can all feel this. What it means is that this white space is getting filled pretty fast. These logos are the companies that got to a billion plus of revenue as a result of the cloud mobile and now AI tectonic shifts. And at current course and speed there are more coming soon.
Pat 3:27 Point number three, which is probably the most interesting one, is that there are two basic kinds of revolutions in technology. There are revolutions of communication which are about the way information is distributed. Most of the people in this room have only lived through revolutions in communication. The internet, the cloud, mobile, those are all about information distribution. AI is different. AI is a revolution in computation. It's about how information is processed. And that might sound like semantics, but these are fundamentally different shapes of waves.
Pat 4:28 And we've had three major inflection points over the last handful of years. First one: Chat GPT moment, November 2022, the world saw the power of pre-training. Second one, couple years later: 01 model reasoning. All of a sudden a second scaling law emerges around inference time compute. Third one just recently: cloud code no plus 45 now 47. The world saw the power of long horizon agents. And while these look like three points on a continuum, it's kind of a heartbreak between two and three. It's a little bit of a discontinuous change. And if we may be so bold we would say that this is AGI.
Pat 5:26 We study businesses. And so from a commercial standpoint, from a practical standpoint, from a functional standpoint, if you can dispatch an agent to do a job and it can recover from failure and persist until that job is done, I don't know. That feels pretty much like AGI. Even if you don't think it's AGI, I think we can all see that the cars have arrived. Last few years we've had a lot of faster horses. Applications that made you 10 or 40% more productive, but didn't fundamentally change the way you work. Now we're starting to see cars. Applications that make you 10 or 40X more productive. And absolutely change the way that you work. Change the nature of your work. Change the nature of your organization. Cars have arrived.
Pat 6:34 So what? Well, it matters cuz just in the last few months the race has begun. And it's a different kind of race than what we're used to. The way you drive a car is different than the way you ride a horse. So it's a very different sort of race. And one of the reasons that we wanted to gather everybody here today is because nobody has all the answers. And the more time we can spend together, the more we can learn and hopefully figure out where all this stuff is headed.
Pat 7:29 So our advice for those of you who are building on top of the labs is free advice and so it's worth every penny you paid for it. Our advice would be to get MAD. And we don't actually need you to be angry. But this is just a convenient acronym for motes, affordance, and diffusion which are three characteristics or three pillars of a strategy for building on top of the models.
Pat 8:35 In a revolution of computation which is about information processing, what you should actually do for the sake of building motes is look up here, because your customers are not changing nearly as fast as the capabilities are changing. The things that you built might be irrelevant tomorrow. The degree to which you wrap yourself around your customers is going to be a bit more durable. In a world where product changes so fast because capabilities change so fast, in thinking about motes, we would encourage you to go as customer back as possible and think about all the ways you can wrap yourself around those customers.
Pat 9:35 The A in MAD stands for affordance. This is a term that we borrow from the design world. A hammer is an object that has affordance. If I give him a hammer, he would know what to do with it. He would grab it and start hitting stuff. An object with affordance is one that doesn't need to be explained. People just know what to do with it. Claude code is insanely powerful. Go open up a terminal for the average Fortune 500 employee and see how far they get. While it is powerful, it does not offer that much affordance. That's an opportunity for anybody who wants to build on top — to create paths of least resistance for your specific customers and their specific problems so that it's just brain dead simple for them to figure out how to get to the outcome that they need for their business.
Pat 10:36 And then finally, the D in MAD is diffusion. And the diffusion gap is the opportunity for companies building at the application layer. The rate at which capabilities are diffusing out into the market is far shy of the rate at which those capabilities are being created. And every day that the foundation models move faster than your average Fortune 500 enterprise, that gap gets bigger and that opportunity gets bigger.
Pat 11:16 Unless that slide from earlier with the white space starting to fill up was discouraging for anybody, may we remind you that no lead is safe. There's this expression in racing. You cannot pass 15 cars in the sun, but you can pass 15 cars in the rain. And right now there is a torrential downpour of new capabilities coming out of the foundation models. Which means that no lead is safe, but it also means that anybody can win. What a time to be alive.
Sonia 12:07 The purpose of my section is to talk about what's happening in AI right now, which for 2026 is agents. Okay, flashback to 2022. Show of hands, does anybody here remember AutoGPT or BabyAGI? These projects were overnight hits on GitHub and what they did was they took GPT-3, gave it some tools, wrapped in a loop, and let it run towards a goal. And it was promising until you watched those agents just fail over and over and over again. Kind of cute, kind of endearing, but completely useless. And I put this slide here to remind us that we all knew agents were coming. But back in 2022, the models just weren't ready yet. Fast forward to today, something around the turn of the year really changed. Suddenly we have agents everywhere around us and they seem to actually be working.
Sonia 13:20 Two agents in particular have been home runs. Claude code for the technical crowd and open claw and all of its lobster brethren, which democratized agents to anybody with a phone. And so, whether you are a hardcore engineer or a normie, the punchline is that anybody can create agents now.
Sonia 13:48 An agent is a system that perceives its environment, chooses actions, and progresses autonomously towards a goal. And more specifically, I view agents as having three functional components. First is the ability to reason and plan. This is the baseline level of intuition and the ability to think on the fly. Second is the ability to take actions. This is tools, search, write, compile. And then finally, the ability to iterate towards a goal. This is the persistence that gives agents the ability to accomplish things over long time horizons. And so, agency combines these three things. It is simply the ability to get done.
Sonia 14:51 First, the models are the brain. This is the most important thing that's happened. The meter chart measures how long a model can sustain progress on a complex task without going off the rails. And we've gone from the order of tens of minutes a year ago to the order of hours today. And so, this is the most important thing that's happened. The models are finally getting capable enough to sustain performance on long horizon tasks.
Sonia 15:17 Second, the tools are the arms and the legs. These give models access to things that make us productive on the computer. The terminal for file systems and dev tools, iMessage, Slack, web search, computer use, you name it. And the last two decades that we spent building tools for humans have ended up being able to port over to be incredibly useful for agents as well. And there's a common refrain that SaaS is dead. I think to the contrary, the value of these tools is going to explode as the number of agents using them increases.
Sonia 16:05 Models and tools give agents capability. The harness is what gives them persistence, the ability to stay on task, adapt, and keep going. And that feedback loop is now really starting to crank. Especially now with reinforcement learning, we're giving these agents we're taking them to driving school, giving them training them in RL gyms, and we're pushing performance in different settings from mechanical engineering to design to finance. We're also seeing the early glimmers of self-improvement or the machine building the machine. For example, Andrej's research project improves research autonomously towards a GPT-2 level model in just 2 hours.
Sonia 17:39 So we're progressing up a scale of agenticness. Agents are going from little helpers that do a little amount by your side to interns that need to be managed to interns that manage themselves. And eventually to interns that can be trusted enough to push to prod without oversight. And so, that's the evolution that's happening not just in coding, but across all of agents.
Sonia 18:01 The most important takeaway for the founders in this room is that services is the new software. In medicine, you're able to hire an agent that inspects your genome, gives you personalized recommendations, can prescribe you medication, recommend you clinical trials. And law, you'll be able to hire agents that can negotiate contracts on your behalf, even perform litigation and settle for you. In math and the sciences, we're seeing agents that can solve air those problems or discover new superconductors. Or in the consumer world, personal agents that can manage your inbox for you, your calendar, your finances, file your taxes.
Sonia 18:54 And we expect there's going to be agents everywhere and that's in part because hiring agents is so much easier than hiring employees. Humans are hard to scale. Infinites are infinitely scalable with compute. Humans are hard to keep happy. Agents are low maintenance. Humans are expensive. You pay them salaries. Uh you pay agents tokens. Generally, it costs less to accomplish a task with tokens than the equivalent in salary. Today, humans are still generally smarter, but the bitter lesson presses on and soon agents will be smarter at many things.
Sonia 19:43 So if you add all this up, the number of agents is ballooning on some sort of exponential, maybe super exponential. And I think we're about to hit the point where things get genuinely strange. What happens when commerce happens between agents? Can they pay each other? What happens when agents can actually negotiate the terms of a transaction with each other? Are we going to have swarms of agents policing us, preventing things like cybersecurity Armageddon? All we know is the world is getting weird extremely quickly.
Sonia 20:17 Long horizon agents are here. The curves that they're on is very clear. And for founders, I think everybody has examples of people that are accomplishing insanely hard timelines thanks to AI. So Nathan from Zed accomplished a three-year moonshot project over the holidays by himself with cloud code. Bret Taylor rebuilt Sierra over a weekend. The Notion team rewrote 8 million lines of code in just 6 weeks. And so everybody has these examples of compressed timelines. But I think very few people outside of the AGI labs have seen what happens when you take these compressed timelines and you stack them on top of each other. And that's what's possible now. And so whatever you could imagine building over the next 100 years, we think is now possible in 100 days thanks to agents.
Constantine 21:17 The goal here is we all know we're in an AI age. What's it going to look like? What's it going to feel like? How's it characterized? Earlier in the presentation, Pat bifurcated technological revolutions between compute and communication. We're going to do another bifurcation here for types of work. There is physical work. Work equals force times distance, physical movement. And then there's cognitive work. Conscious thinking. These are very different types of work. But we believe that they're going to follow a very similar pattern in revolution.
Constantine 22:13 For the vast majority of human history, all the work for serving humans was done by some sort of muscle. People or animals. Then things started to change. Water and wind. Steam engines. And then things accelerated. Steam engines, combustion, electric motors. Today, 2026, you could estimate that 99 plus percent of all the physical work done on planet Earth for humans is done by machine. The plane that brought you here, the manufacturing of all the goods in this room, all the transportation that sets up for the pinnacle of the human experience you're having right now. Well, we think a similar pattern's going to happen in cognition. We're just a little earlier on.
Constantine 23:43 So for most of human history, all the thinking on planet Earth for humans was done primarily by humans. Maybe a little bit for animals. The sheepdog chasing the sheep. And there was this sliver on top of mechanical work, the astrolabe or the clock. Now, over the past couple hundred years, there was not a lot of progress until electronic computation. And in the past 100 years, think about all the trillions of calculations that are happening at any given moment to serve you the human. All of that work, all of that cognitive work that's happening to serve us at any given moment. Trillions of calculations. We believe that the neural network is the next big wave. And that in the near future, 99.9% of cognition on planet Earth will be done by machines.
Constantine 24:45 The cognitive revolution is going to be a lot like the Industrial Revolution. Just much, much bigger and much faster.
Constantine 24:59 In the mid-1800s, America wanted to build a grand monument to our first president and our greatest war hero, George Washington. So we designed the tallest building in the world at the time, the Washington National Monument, and we wanted to cap it with the most precious metal in the world, 100 oz of the most precious metal in the world. So precious, in fact, that we put it on display at Tiffany's in Manhattan. That metal was aluminum. Within decades of the completion of the Washington National Monument, a young inventor came up with electrolysis, the process of separating aluminum from dirt. And within decades, aluminum was used to wrap our candies and our sandwiches, and then tossed into the trash. Aluminum is intelligence. Electrolysis is artificial intelligence. We're about to enter a world where some of the most precious skills that took decades to earn, PhD-level skills, are so instantly invoked that right after using them, you can crumple them up and throw them right in the trash.
Constantine 26:28 We are entering a world of alien design. The world as we see it today is all about design for humans. It's been optimized in a way that makes sense to our brains because we are doing almost all the cognition in the world. Well, when machines do the cognition, it's going to be a little different. In 2006, NASA was optimizing an antenna for a large space mission. Traditionally, their antennas looked like this. It was a beautiful geometric, symmetrical pattern that optimized surface area for some power constraints. This time around, they said, "We're going to hand it over to computer and we're going to have an evolutionary algorithm." A lot like reinforcement learning. The result, this antenna right here. Dramatically more productive. Not intuitive to the human mind. In this AI era, when we hand over cognition to machines, we're going to get results that are not intuitive to us. When AI's designing chips, cars, buildings, they might look dramatically different. The world that we enter into, we have to be open-minded because the AI is not going to think like us. It's going to have alien design.
Constantine 27:50 In the early Industrial Revolution, you had great engineers like Newcomen and Watt. And they perfected combustion engines. Basically, put a petrochemical into a piston, ignite it on fire, millions, billions of particles explode, move the piston, work. For almost 100 years, all of that was tinkering. It was an engineer saying, "Ah, that works a little bit better." Maybe something you could see like a scaling law, but it was engineers playing with the product and seeing how they could improve it a little bit. Over 120 years after Sadi Carnot came around and formalized this in a new science, thermodynamics. He said, "Wait a second. There are millions or billions of particles. We can actually formalize what that all looks like." In this case, there are billions of neurons, trillions of tokens. Right now, we're in the tinkering phase of AI. Even if we think it's an understood science, it's not. In the future, we will have a science as fundamental as thermodynamics introduced in the next couple decades. Someone in this room might come up with that science. And that science will be taught in high schools. It will be that fundamental. And it will help us master AI. It will even help us master consciousness.
Constantine 29:24 For the vast majority of human history, tens of thousands of years, art has been a progression towards realism. This is a cave painting from about 25,000 years ago. Egyptian hieroglyphs. Greek pottery. Renaissance paintings. A grand transformation toward realistic art. Just look at the difference over tens of thousands of years, the triumph of humanity. And then, engineering came along. The daguerreotype, early photography. And all of a sudden, what was spent decades of life to perfect the skill of getting every brushstroke perfect, done. So, how did the world react? They thought that painting was over. Art is ended. Well, what happened? How did humans respond? Humans responded by saying, "Was the purpose of this art to capture the moment in the way the eye sees it? Or was it to capture the moment in the way the heart and the soul sees it?" Impressionism, expressionism, cubism, neo-expressionism. All these new forms of art are how humanity responded to this dramatic change in science.
Constantine 31:08 2,500 years ago, Greek philosopher Protagoras wrote, "Man is the measure of all things." What he meant is that nothing in a vacuum has value to humans. Not aluminum, not art, not intelligence. It only has value because of the experience. AI can do the work. AI will do the work. But, only the human connection can give you a reason to care. That's why we're all in this room today. A decade from now, work is going to be dramatically different. Things are going to change so much, but the one thing that will be constant is the relationships that you form today with the person right next to you will endure. That's what you're going to look back on. That's what's going to be valuable from today. So, I encourage you to form those relationships with the people next to you. Enjoy your time together at this AI Ascent, and really lean into what makes us most human.